Written By Unknown on Selasa, 31 Maret 2015 | 23.17
Adrenal hyperplasia is a rare genetic condition that involves the adrenal glands, which lie just above the kidneys.
It results in a blockage in the assembly line that makes the stress hormone cortisol from its chemical precursors.
People with the condition have low levels of cortisol, which helps to regulate blood sugar levels. If they fall too low, it can result in a coma.
But in some cases, the blockage can also reduce the production of aldosterone, a hormone involved in the regulation of salt in the bloodstream.
If salt levels fall too low it can lead to dehydration, vomiting and death.
Regular treatment with steroid medicines can help to maintain normal hormone levels and although the condition is lifelong, the outlook is generally good.
But Malakhi is now likely to have missed two doses of his medication and there is increasing concern for his welfare.
Revised official figures show that the UK economy grew last year at the fastest pace since 2006.
The Office for National Statistics (ONS) said the economy expanded at 2.8% in 2014, approaching the figure of 3% seen eight years before.
The ONS boosted the figure after a standard revision to growth in the last quarter of 2014 was calculated.
It said Q4 growth was 0.6%, up from the previous estimate of 0.5%.
This took growth for the whole of 2014 to 2.8%, from the earlier published figure of 2.6%.
Video:Weak Inflation 'Will Drive Growth'
It said several factors were behind the greater pace increase, including a big boost to exports, along with increased household spending and services spending.
The ONS made the announcement at the same time as revealing the latest current account figures for income received and liabilities paid to the rest of the world.
It said the record current account deficit of £27.7bn in Q3 had been reduced to £25.3bn by the end of December.
Video:UK: Global Economy's "Bright Light"
New measures to calculate wellbeing of households were also released by the ONS.
It said real household disposable income increased by 1.9% last year, but overall it showed only a 0.2% increase from the figure at the end of Q2 in 2010.
It said household optimism over finances has continued to increase from a low point seen at the start of 2012.
Zayn Malik may have left One Direction on good terms - but all that could be about to change.
Just days after announcing his departure from the band so he could be a "normal" 22-year-old, a demo recording of Malik performing on his own has been posted online by a renowned producer.
Louis Tomlinson, one of his former bandmates, went crazy, crazy, crazy when he heard the song.
In a tweet to the producer behind the leak, Naughty Boy, he wrote: "Wow @NaughtyBoyMusic you're so inconsiderate pal, seriously how f****** old are you? Grow up!"
Tomlinson accused the British DJ of trying to wind up One Direction fans, who are still nursing broken hearts after the five-piece band became four – prompting fears a split was imminent.
1/20
Gallery: One Direction Through The Years
One Direction members Harry Styles, Louis Tomlinson, Liam Payne, Zayn Malik and Niall Horan on a chat show at the end of 2014
Horan enjoys a tennis match at the Australian Open in January 2015
Winds of up to 70mph battered parts of England and Wales overnight, causing widespread travel disruption and flooding in some regions.
In the northwest, firefighters spent three hours removing a 20ft tree which had fallen onto a house in Leigh - ruining a family's plans to go on holiday.
And at an Esso refinery in Hampshire, a crewman was rescued from a sinking tug by a heroic employee who jumped into the water to save him.
In Worsley, a 20ft tree fell onto a house. Pic: @manchesterfire
Without hesitation, he swam to the capsized vessel and smashed a window to help the trapped crew member, who only had access to a small pocket of air inside.
All of the employees have been accounted for, according to the coastguard - although one person had to be treated for hypothermia following the incident.
Video:Sky News UK Weather Update
Earlier, journeys on the West Coast Main Line between Warrington and the Lake District were delayed by up to an hour - while trees on the line caused considerable disruption between Exeter and Taunton, Salisbury and Romsey, and Aylesbury and London.
Several bridges on the motorways were closed as a precaution, including the Dartford Crossing on the M25, the Severn Bridge on the M48, and the Ouse Bridge on the M62.
There was also bad news for fans of the Thunderbirds, as an event to promote the new series on the River Thames was cancelled.
Although it will "gradually quieten down" as the Easter weekend approaches, the Met Office predicts the strongest winds are yet to be seen in northwest England.
And, even though it is the first day of April on Wednesday, wintry showers are expected over higher ground in Scotland, spreading into northern England and parts of north Wales.
Sky News weather producer Becky Yussuf said: "The unsettled, wet and windy weather will continue through until Good Friday.
"High pressure will build across the UK and Ireland over the Easter weekend, bringing largely dry and settled conditions.
"There is expected to be a lot of cloud around, and so brightness might be at a bit of a premium.
"Temperatures will be around average for the time of year, with highs of 14C (57F)."
The Conservative leader has refused to say where welfare cuts will fall but insisted that British families still needed to take "the medicine" to help put the country back on track.
In a round of interviews setting out a pledge to create two million extra jobs over the course of the next parliament, David Cameron admitted there were more cuts to be made but would not say where they would fall.
The Conservatives have said they will find £12bn of welfare cuts over the next parliament if they are returned to power on 7 May but have indicated they will not tell voters of the details before the vote.
:: For full coverage of the General Election 2015 click here
Tackled on where the cuts would fall on Sky News Mr Cameron said: "The medicine is that we need to - for two more years - do what we have done for the last five, which is find £1 out of every £100 the Government spends and save it.
Video:Tories Try To 'Pull Wool Over Eyes'
"So the choice at this election, if you simplify it, really is: do you want to find that £1 saving out of every £100, which families and businesses up and down the country have had to do or do you want to scrap that plan and put up taxes and borrow more."
Mr Cameron said that they had managed to find £20bn of welfare savings in the last five years.
Answering claims he would go down as the "biggest Scrooge prime minister", Mr Cameron said he didn't come into office to make cuts but when he came to power Britain had a budget deficit forecast to be bigger than that of Greece and he had to do the job.
He also dismissed criticism over using his outgoing address at Number 10, at which he officially announces the General Election, to attack his opponent Ed Miliband.
He was the first prime minister to use the platform to speak against the opposition leader but when asked if it was "not cricket", Mr Cameron told Sky's Eamonn Holmes: "In cricket there are two opposing teams".
Video:Cameron's Election Pledge
And after reports of meetings between Tory MPs and UKIP members he denied he had been in "secret talks" over a coalition and intended to spend the next 37 days working for a majority.
He also said that his wife, Samantha, had not been behind his decision to announce he would only serve two terms as Prime Minister.
Mr Cameron believes the Tories can match the job creation of the past five years, during which the Coalition created an average of 1,000 new jobs every day. Although he got his figures mixed up during the interview on Sky News and claimed it had been 10,000 a day.
As the second day of campaigning gets under way, the Prime Minister said: "We are the jobs party - and over the next month, we will be fighting for every man and woman who wants to work and earn a wage."
The pledge comes exactly a year after Chancellor George Osborne set a goal of full employment for Britain.
Video:Cameron: Voters Face 'Stark Choice'
Mr Cameron argues an additional two million jobs is a feasible target thanks to government assistance for business, competitive tax rates, a parliament-long campaign against red tape, plus investment in infrastructure.
He said Labour's plan to reverse corporation tax cuts - as a way of paying for a reduction in rates for small businesses - was a "crazy thing to do when the economy is growing".
The Prime Minister's first outing of the election campaign proper was to address a rally of supporters at a school in Chippenham - a marginal constituency they need to take if they are to stand any chance of winning a majority.
Speaking at the event, Mr Cameron admitted he is not the "perfect" Prime Minister - but insisted he has a record to be "proud" of.
It came figures from the Office for National Statistics showed that the UK economy grew faster than had been expected - 2.8% in 2014, which was 0.2% higher than earlier estimates.
Video:Miliband: 'Two Futures On Offer'
Nick Clegg and the Liberal Democrats sought to distinguish themselves from the Conservatives, and other parties, by focusing on mental health with a pledge of extra funding.
He accused the Tories of trying to "pull the wool over people's eyes" on NHS funding by refusing to set out clearly for voters how it would pay for its pledges on the health service.
The Lib Dems were the first party to commit to meeting the extra £8bn the NHS chief Simon Stevens said was needed for the health service to survive by 2020.
Mr Clegg also criticised Mr Cameron's refusal to say where welfare cuts will fall and said: "The Conservatives are trying to treat people like fools. They say they are going to take £12 billion away from the poorest families in the country but they won't spell out how or where. They are promising everybody lashings of tax cuts but won't tell people how they are going to pay for it."
On the first day of Labour's campaign, Mr Miliband tried to win over business with the launch of the party's first "mini manifesto".
Video:Election: Day One In 60 Seconds
:: Watch the seven-way leaders' debate live and in full from 8pm on Thursday on Sky News, on Sky channel 501, Virgin Media channel 602, Freeview channel 132, Freesat channel 202, and on the Sky News website.
Labour has pledged to reverse the Government's final cut in corporation tax to pay for a reduction in rates for small businesses.
Shadow Chancellor Ed Balls has also promised smaller firms they will be the first to benefit from future tax cuts if Labour takes power in the General Election.
Mr Balls said that reversing the corporation tax cut would allow Labour to slash business rates on 1.5 million small business premises.
:: For full coverage of the General Election 2015 click here
Labour argues that 17 small firms would benefit from the cut for every large business helped by the reduction in corporation tax.
Video:Miliband's Pitch To Business
The party claims the coalition spent £7bn over the last parliament cutting the main rate of corporation tax to the benefit of larger firms, while revenues from business rates rose by £3bn.
Speaking as he visited a small business, Mr Balls said: "Unleashing the potential of smaller businesses to grow, create more good jobs and raise living standards is a vital part of Labour's better plan.
"This is part of our plan to deliver a simpler and fairer tax system for small businesses. This is the right priority when money is tight.
Video:Cameron: Voters Face 'Stark Choice'
"And it will mean that the tax burden on small businesses will be lower with Labour than under the Tories."
The announcement comes a day after the launch of Ed Miliband's business manifesto was overshadowed by a row over Labour's use of business leaders' quotes in an advert for the party's stance on the EU.
Mr Miliband faced a backlash over the advertisement in the Financial Times, published as Mr Miliband warned voters that leaving the European Union was a "clear and present danger" to British business.
Video:Miliband: 'Two Futures On Offer'
The Conservatives have argued that abandoning the cut in corporation tax would jeopardise economic security.
Treasury Minister David Gauke said: "This would be the first time corporation tax has risen in over 40 years and Labour's plans could cost 96,400 jobs - it would put people's economic security at risk.
"The Conservative Party is helping businesses small and large as part of our long-term economic plan - we don't divide them up for the sake of making a political point."
Video:Election: Day One In 60 Seconds
David Cameron said reversing the corporation tax cut was a "crazy thing to do when the economy is growing".
The Conservative leader today pledged a Conservative government will help business create two million new jobs over the course of the next parliament.
Nick Clegg was speaking earlier to promised an additional £3.5bn over the next parliament, with the aim of "revolutionising" adult and child mental health care.
Police have made an urgent public appeal for help locating a convicted murderer who has breached his release licence.
53-year-old William Kerr, who was jailed for life for murder in 1998 before being released on licence on 23 January, is wanted for emergency recall to prison.
Detectives have described Kerr as "dangerous" and warned the public not to approach him.
North Yorkshire Police were asked for help locating Kerr after the National Offender Management service said he had absconded from approved premises in Hull.
He is known to have links in Humberside, West Yorkshire and London, but his current whereabouts are not known.
Detective Inspector Eamonn Clarke said: "To assist our already extensive efforts to trace William Kerr, I am urging people to keep an eye out for the man in the photographs.
"We ask that you do not approach Kerr, as he is considered dangerous. You should contact the police straight away on 999 and officers will be dispatched to arrest him or investigate the sighting."
The police have also made a direct appeal to Kerr, saying: "William, you know you have breached your licence conditions, and by continuing to do so you are only making things worse. It is now time to do the right thing and hand yourself in to the police."
:: Anyone with information about William Kerr is urged to dial 999 to pass details to North Yorkshire Police, or contact Crimestoppers on 0800 555 111, quoting North Yorkshire Police reference number 12150049525.
Lord Ashcroft has retired from the House of Lords with immediate effect, to concentrate on his "other activities".
The 69-year-old hinted he would retain his title, writing on his Twitter page: "Retired Lords keep their title and can use the facilities of the House should they wish to."
"Earlier this year Baroness D'Souza, the Lord Speaker, said that any member of the House of Lords who can 'no longer contribute meaningfully' should retire," he said in a statement posted on his website.
"She added that since the House has close to 800 members, 'retirement at the right time should be seen as a condition of membership of the House of Lords - a duty as well as a right'.
"I agree with the Speaker, and have concluded that my other activities do not permit me to devote the time that membership of the Lords properly requires.
"Accordingly, I have today written to the Clerk of the Parliaments giving notice of my resignation from the House of Lords with immediate effect."
Lord Ashcroft, who remains a life peer, said he intended to continue his involvement through his polling organisation and his publishing interests.
A former Deputy Chairman and treasurer of the Conservative Party, Lord Ashcroft has a range of business interests and was estimated in 2009 to be worth around £1.1bn.
He hit the headlines in 2010 when, after 10 years of keeping his tax status private, he admitted he did not pay tax on his overseas earnings in the UK.
A 10-year-old boy with a rare genetic condition, who went missing from his south London home this morning, has been found and taken to hospital.
Malakhi Chijiutomi-Ghosh, who requires medication three times a day, was discovered by an off-duty police officer in Cheshunt, Hertfordshire.
Police had said they were "extremely concerned" for the welfare of the child because he had not had his medicine today.
Malakhi suffers from congenital adrenal hyperplasia and officers said there was a "real chance" he could have fallen into a coma had he not been found.
After he was discovered, the child was taken to hospital as a precaution.
Police launched a major appeal and search after Malakhi left his home in Thornton Heath, Croydon, at 6am without a mobile phone, cash or Oyster card.
Police had been searching for the boy in south London
The boy, who likes trains, was last seen at a bus stop in nearby Streatham Common around two hours later.
His disappearance was said to be "completely out of character" and his parents had been "distraught".
Congenital adrenal hyperplasia (CAH) causes swelling of the adrenal glands and in its most severe form can be life-threatening.
CAH means the body is missing a chemical substance which stimulates the adrenal glands to release the cortisol hormone.
People with the condition are less able to cope with emotional and physical stress, the NHS said.
The condition makes the level of male hormones increase. Symptoms include heart rhythm abnormalities, dehydration and vomiting.
CAH affects between one in 10,000 and one in 18,000 children born each year.
By Mark Stone in Beijing and King Chai Woon in Kuala Lumpur
A 23-year-old man has been sentenced to death for the killing of two British medical students on the island of Borneo last August.
Fishmonger Zulkipli Abdullah faces death by hanging once his appeals has been exhausted.
Newcastle University students Neil Dalton and Aidan Brunger, both 22, were found lying in a road in Kuching, the capital of Malaysia's Sarawak state, on 6 August.
An inquest heard how they were stabbed to death following an incident at a bar or cafe in the early hours of the morning.
Prosecutor Muhamad Iskandar Ahmad said Zulkipli admitted to the court that he was involved in a fight with the two Britons, along with two of his friends, but claimed he punched one of them rather than stabbing either of them.
Video:Aug 2014: Arrests Over Stabbings
The two men with him on the night testified for the prosecution and said Zulkipli told them he wanted to "test his power" against bigger and taller foreigners.
After the killing, he sniffed the blood on his hands and told his friends that "the blood of white men smells nice," the prosecutor said.
But speaking to Sky News, Zulkipli's defence counsel Anthony Tai said he believes there are "material, fundamental contradictions" by one of the witnesses, who changed her story and testimony.
According to Mr Tai, the unnamed witness initially told the police that she saw three people getting out of a car to attack one foreigner, but during cross-examination, she said she was "mistaken" and claimed that only one person got out of the car and attacked two foreigners.
Mr Tai described the contradictions by the witness as "lies" and expressed surprise that the court still found her to be credible. He said the contradictions will be an important issue during the appeal process.
The fourth-year students were in the Malaysian part of the island on attachment to a hospital in Kuching and were due to finish their placements two days after they were killed.
In a joint statement, their parents said they were "pleased" with the verdict but added it would not bring their sons back.
"They were two exceptional young men with such promise - kind, funny and full of life," Phil and Jan Dalton and Paul Brunger and Sue Hidson said.
"Their deaths have left their families and many good friends utterly devastated.
"Our sons would soon have qualified as doctors. Their unprovoked and senseless murders as they were walking home after a night out with other medical students mean that Aidan and Neil will never have the chance to spend their lives caring for and helping others.
"They would have given so much to the world. We are so very proud of both of them and in what they achieved in their all too short lives.
"Although we are pleased that the man responsible for their murders has been held accountable, the guilty verdict does not bring our sons back."
