Police searching for missing teenager Jayden Parkinson say they have found a suitcase that may be "significant" to their inquiry.
Detective Chief Superintendent Andy Murray said officers have found a number of suitcases but one in particular may be of interest.
Police have still not found the teenager's body, but have received information that indicates Jayden, 17, is no longer alive.
They have appealed for information about a man seen struggling with a large suitcase in the early hours of Monday December 9 in the village of Upton, Oxfordshire.
Witnesses saw the man with the suitcase a short time later in the nearby town of Didcot.
Jayden was last seen leaving Didcot Parkway railway station on December 3.
Ben Blakeley, 22, from Christchurch Road, Reading, who is accused of Jayden's murder, has been remanded in custody and is due to appear in court again on March 17.
A 17-year-old boy from Didcot has been charged with perverting the course of justice.
Det Ch Supt Murray told Sky News that 50 detectives and "as many and more" uniformed officers are now committed to the search for Jayden.
He told Sky's Kay Burley that specialist search and forensic officers were searching an area of open farmland, woodland and derelict buildings that are of "particular significance".
He said reports that Jayden may have been pregnant when she went missing were "speculation".
The teenager had been living with her mother in Didcot until November but most recently had been staying at a hostel in Oxford.
Det Ch Supt Murray said Jayden's "distraught" family are living through "every parent's worst nightmare".
He issued a direct appeal to certain people who he believes may have crucial information about what happened to the teenager.
He said: "I'm asking them to think about what they've been doing in the last week or so, examine their consciences and take the courage to pick up the phone.
"They need to be thinking about Jayden's parents at this time and they need to be giving us a call to assist with this inquiry."
:: Watch Sky News live on television, on Sky channel 501, Virgin Media channel 602 and Freeview channel 82.
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